Acute generalized exanthematous pustulosis induced by itraconazole: an immunological approach.
Clin Exp Dermatol
; 34(8): e709-11, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-20055840
ABSTRACT
Acute generalized exanthematous pustulosis (AGEP) is an uncommon disease, which presents as a nonfollicular erythematous sterile pustular eruption. More than 90% of the cases are induced by adverse drug reactions, often triggered by anti-infectious systemic drugs. We report a case of itraconazole-induced AGEP in a 22-year-old man, with an assessment of his cytokine/chemokine production and drug-specific cell reactivity. We found that AGEP, like other T cell-mediated drug eruptions, alters the immunological status of the patient, probably favouring T-cell activation, recruitment and regulation. Few cases of itraconazole-induced AGEP have been described in the literature, and to our knowledge, this is the first report in which the cellular immunological features are assessed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Toxidermias
/
Itraconazol
/
Pustulose Exantematosa Aguda Generalizada
/
Antifúngicos
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Clin Exp Dermatol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil