[Testing of antibodies against serogroup C Neisseria meningitidis by serum bactericidal assay in healthy population, Liaoning province].
Zhongguo Yi Miao He Mian Yi
; 15(5): 456-8, 2009 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-20084976
ABSTRACT
OBJECTIVE:
To test the serum antibodies from healthy population by Serum Bactericidal Assay (SBA), in order to evaluate the level of protective antibodies against serogroup C Neisseria meningitidis in Liaoning province.METHODS:
240 serum samples were selected from eight age-group randomly. Serogroup C vaccine candidate strain (C11) and the prevail serogroup C strain (053442) were used for SBA.RESULTS:
48.33% of 240 serum samples were positive (titer > or = 12) to C11 vaccine strain. Protective rate of SBA was 35.83% (titer > or = 18), in which, > or = 6 years old were 13.33%, 7-19 years old was 61.67%, 20-39 years old were 46.67% and > or = 40 years old were 63.33%. Rate of SBA to 053442 was lower than that to C11 in the group over 15 years old by statistic analysis.CONCLUSION:
Population under 6 years old showed lower SBA capacities. With the implemention of Expanded Program on Immunization, children under 3 years old should be considered how to give them meningococcal vaccine in order to improve the titer of antibodies against Neisseria meningitidis serogroup C.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atividade Bactericida do Sangue
/
Neisseria meningitidis Sorogrupo C
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Infecções Meningocócicas
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Anticorpos Antibacterianos
Tipo de estudo:
Screening_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
/
Female
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Humans
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Infant
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Zhongguo Yi Miao He Mian Yi
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China