Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation.
J Biomech
; 43(6): 1061-6, 2010 Apr 19.
Article
em En
| MEDLINE
| ID: mdl-20116061
ABSTRACT
Bone mass distribution and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels. Mechanical stimulation of bone induces new bone formation in vivo and increases the metabolic activity and gene expression of osteoblasts in culture. A wide variety of devices have been tested for mechanical stimulation of cells and tissues in vitro. The aim of this work was to experimentally validate the possibility to use piezoelectric materials as a mean of mechanical stimulation of bone cells, by converse piezoelectric effect. To estimate the magnitude and the distribution of strain, finite numerical models were applied and the results were complemented with the optical tests (Electronic Speckle Pattern Interferometric Process). In this work, osteoblasts were grown on the surface of a piezoelectric material, both in static and dynamic conditions at low frequencies, and total protein, cell viability and nitric oxide measurement comparisons are presented.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
Limite:
Animals
Idioma:
En
Revista:
J Biomech
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Portugal