Metabolism of almitrine in extensive and poor metabolisers of debrisoquine/sparteine.
Br J Clin Pharmacol
; 31(1): 73-6, 1991 Jan.
Article
em En
| MEDLINE
| ID: mdl-2015173
ABSTRACT
1. Almitrine bismesylate displays wide inter-subject variation in peak plasma concentrations and can induce peripheral polyneuropathy. 2. The phenotyped volunteer panel approach was used to examine whether almitrine oxidation displayed a genetic polymorphism of the debrisoquine/sparteine type. 3. There was no difference between poor and extensive metabolisers of debrisoquine with respect to the pharmacokinetics and metabolism of almitrine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esparteína
/
Almitrina
/
Debrisoquina
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Br J Clin Pharmacol
Ano de publicação:
1991
Tipo de documento:
Article