Nonmuscle myosin II localization is regulated by JNK during Drosophila larval wound healing.
Biochem Biophys Res Commun
; 393(4): 656-61, 2010 Mar 19.
Article
em En
| MEDLINE
| ID: mdl-20153725
ABSTRACT
We investigated cell shape changes during wound closure in the Drosophila larval epidermis. During reepithelialization, epidermal cells permanently change shape from pentagonal or hexagonal to irregular forms. This process requires zipper, a gene encoding the Drosophila nonmuscle myosin II heavy chain. Following wounding, myosin II is localized at the wound margin and at the rear end of individual cells located within several rows from the wound hole. The c-Jun N-terminal kinase (JNK) pathway is essential for this myosin II localization. These results suggest that not only the wound leading edge but also the cells lying distal to the leading edge cells actively participate in epithelial cell sheet migration during wound hole closure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Cadeias Pesadas de Miosina
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Proteínas de Drosophila
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Proteínas Quinases JNK Ativadas por Mitógeno
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Drosophila melanogaster
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Epiderme
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Proteínas de Membrana
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2010
Tipo de documento:
Article