Metformin induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients.
Clin Biochem
; 43(9): 759-60, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20214894
ABSTRACT
OBJECTIVE:
To study the effect of short term metformin therapy on plasma levels of cobalamin, cobalamin related metabolites and cobalamin binding proteins in elderly patients. DESIGN ANDMETHODS:
Twenty patients with type 2 diabetes were assigned to receive metformin or not for 3 months. Cobalamin and its metabolites were measured before and after metformin therapy.RESULTS:
As compared to baseline measures, there was a metformin therapy specific significant decrease in plasma levels of total cobalamin, total haptocorrin and haptocorrin bound cobalamin.CONCLUSIONS:
Plasma total cobalamin and haptocorrin bound cobalamin levels are reduced by short term metformin therapy in an elderly diabetic population. Larger scale, longer term studies are necessary to determine if there is an unequivocal decrease in functional measures of cobalamin status.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina B 12
/
Transcobalaminas
/
Regulação para Baixo
/
Diabetes Mellitus Tipo 2
/
Metformina
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Biochem
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Canadá