The effect of phenylpropanolamine on 24-hour blood pressure in normotensive subjects administered indomethacin.
DICP
; 25(3): 234-9, 1991 Mar.
Article
em En
| MEDLINE
| ID: mdl-2028627
ABSTRACT
We evaluated the effect of phenylpropanolamine hydrochloride (PPA) in 14 young, healthy, normotensive women who concurrently received indomethacin. Subjects received sustained-release (SR) indomethacin 75 mg bid and were randomly assigned to receive double-blind SR PPA 75 mg/d or placebo for four days. After a six-day washout period, subjects were crossed over to the opposite four-day double-blind treatment. Following an additional six-day washout period, subjects received indomethacin placebo and PPA placebo during a final, single-blind four-day period. Twenty-four-hour blood pressure (BP) monitoring every 30 minutes and a 24-hour urine collection for prostaglandin E2 (PGE2) were performed on the fourth day of each treatment period. Compliance with the medication regimen was confirmed by drug concentrations, pill counts, and urinary PGE2 concentrations. Compared with the indomethacin and placebo treatment periods, the combination of indomethacin and PPA had no significant effect on mean systolic or diastolic BP during the 24-hour study period or during any four-hour interval. We conclude that the combination of SR PPA 75 mg/d and SR indomethacin 150 mg/d for four days has no adverse effect on BP in normotensive women.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilpropanolamina
/
Pressão Sanguínea
/
Indometacina
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
DICP
Assunto da revista:
FARMACIA
/
FARMACOLOGIA
Ano de publicação:
1991
Tipo de documento:
Article
País de publicação:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA