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Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation.
Liu, Wen-Shan; Hsin, Chung-Han; Chou, Ying-Hsiang; Liu, Jung-Tung; Wu, Ming-Fang; Tseng, Szu-Wen; Lee, Jong-Kang; Tseng, Hsien-Chun; Wang, Tzu-Hwei; Su, Mao-Chang; Lee, Huei.
Afiliação
  • Liu WS; Departments of Radiation Oncology, Chung Shan Medical University Hospital, No 110, Sec 1, Chien-Kuo N Rd, Taichung 402, Taiwan.
BMC Cancer ; 10: 102, 2010 Mar 18.
Article em En | MEDLINE | ID: mdl-20298550
ABSTRACT

BACKGROUND:

The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy.

METHODS:

Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrolled and underwent concurrent chemoradiotherapy. The chemotherapy regimens were monthly cisplatin and 5-fluorouracil for six patients and weekly cisplatin for 19 patients. All patients were treated with IMRT with simultaneous integrated boost technique. Acute and late toxicities were recorded based on CTCAE 3.0 (Common Terminology Criteria for Adverse Events).

RESULTS:

The median follow-up time for survivors was 53.0 months (range 36-82 months). The initial complete response rate was 85.2%, with a laryngeal preservation rate of 63.0%. The 5-year functional laryngeal, local-regional control, disease-free and overall survival rates were 59.7%, 63.3%, 51.0% and 34.8%, respectively. The most common greater than or equal to grade 3 acute and late effects were dysphagia (63.0%, 17 of 27 patients) and laryngeal stricture (18.5%, 5 of 27 patients), respectively. Patients belonging to the high risk group showed significantly higher risk of tracheostomy compared to the low risk group (p = 0.014).

CONCLUSIONS:

After long-term follow-up, our results confirmed that patients with hypopharyngeal carcinoma treated with IMRT concurrent with platinum-based chemotherapy attain high functional laryngeal and local-regional control survival rates. However, the late effect of laryngeal stricture remains a problem, particularly for high risk group patients.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Hipofaríngeas / Cisplatino / Laringe Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Hipofaríngeas / Cisplatino / Laringe Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Taiwan