Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma.
J Ethnopharmacol
; 129(2): 208-13, 2010 May 27.
Article
em En
| MEDLINE
| ID: mdl-20307637
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Butea monosperma (Lam.) (Fabaceae) popularly known as 'flame of the forest' has been widely used in the traditional Indian medical system of 'Ayurveda' for the treatment of a variety of ailments including liver disorders. AIM OF THE STUDY To evaluate the antioxidative, anti-inflammatory, hepatoprotective and anti-cancer activities of the aqueous extract of Butea monosperma flowers. MATERIALS AND METHODS:
Dried flowers of Butea monosperma were extracted with water. The extract was tested for its anti-proliferative, pro-apoptotic and anti-carcinogenic effects in hepatoma cell lines. The chemopreventive and anti-angiogenic effects of the extract were evaluated by its daily oral administration in a HBV-related X15-myc mouse model of hepatocellular carcinoma (HCC).RESULTS:
Treatment with the aqueous extract inhibited cell proliferation and accumulation of cells in G1 phase. This was accompanied by a marked reduction in the levels of activated Erk1/2 and SAPK/JNK and induction of apoptotic cell death. Oral administration of the extract in transgenic mice conferred hepatoprotection as is evident from normal serum ALT levels and improved liver histopathology and lowered serum VEGF level.CONCLUSIONS:
The ability of aqueous extract of Butea monosperma flowers to impose growth arrest and trigger pro-apoptotic death in cell culture strongly correlated with its strong chemopreventive effect in vivo when given orally.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Carcinoma Hepatocelular
/
Butea
/
Proliferação de Células
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Neoplasias Hepáticas
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Fitoterapia
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Índia
País de publicação:
IE
/
IRELAND
/
IRLANDA