Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus.
Science
; 328(5976): 357-60, 2010 Apr 16.
Article
em En
| MEDLINE
| ID: mdl-20339031
ABSTRACT
The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Hemaglutininação de Vírus da Influenza
/
Influenza Humana
/
Vírus da Influenza A Subtipo H1N1
/
Hemaglutininas Virais
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos