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Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans.
Forman, John P; Williams, Jonathan S; Fisher, Naomi D L.
Afiliação
  • Forman JP; Renal Division and Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. jforman@partners.org
Hypertension ; 55(5): 1283-8, 2010 May.
Article em En | MEDLINE | ID: mdl-20351344
Vitamin D regulates the renin-angiotensin system (RAS) in experimental animals, but corresponding human data are limited. We examined the relation between plasma 25-hydroxyvitamin D and elements of the RAS in 184 normotensive individuals in high sodium balance; these included circulating levels of plasma renin activity and angiotensin II (Ang II) and the renal plasma flow response to infused Ang II, which is an indirect measure of the intrinsic RAS activity in the kidney. Compared with individuals with sufficient 25-hydroxyvitamin D levels (> or = 30.0 ng/mL), those with insufficiency (15.0 to 29.9 ng/mL) and deficiency (<15.0 ng/mL) had higher circulating Ang II levels (P for trend=0.03). Moreover, those with vitamin D deficiency had significantly blunted renal plasma flow responses to infused Ang II (mean decrease of 115 mL/min per 1.73 m(2) in renal plasma flow versus 145 mL/min per 1.73 m(2) among those with sufficient vitamin D levels; P for trend=0.009). Although plasma renin activity was higher among individuals with insufficient levels of vitamin D, the result was not statistically significant. These data suggest that low plasma 25-hydroxyvitamin D levels may result in upregulation of the RAS in otherwise healthy humans.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Renina-Angiotensina / Vitamina D / Angiotensina II / Sódio na Dieta Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Hypertension Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Renina-Angiotensina / Vitamina D / Angiotensina II / Sódio na Dieta Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Hypertension Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos