An alternative synthesis of 1,1'-bis-valienamine from D-glucose.
J Org Chem
; 75(10): 3522-5, 2010 May 21.
Article
em En
| MEDLINE
| ID: mdl-20392097
ABSTRACT
An alternative synthesis of 1,1'-bis-valienamine 5, which was demonstrated to be a potent trehalase inhibitor, has been achieved from d-glucose in 12 steps with 15% overall yield via enone 12 as the key intermediate, involving a direct aldol reaction of a glucose-derived diketone and a palladium-catalyzed allylic coupling reaction as the key steps.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cicloexenos
/
Glucose
/
Hexosaminas
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Hong Kong