Effect of AMP on acute carbon-tetrachloride hepatotoxicity.
Z Ernahrungswiss
; 16(4): 256-61, 1977 Dec.
Article
em En
| MEDLINE
| ID: mdl-204115
ABSTRACT
The effect of carbon-tetrachloride poisoning and the protection caused by AMP were studied. A single dose of CCl4 has resulted in a rapid development of a fatty liver, a considerable increase in serum enzymes, glutamic oxalacetic and pyruvic transaminases as well as serum-alkaline phosphatase. Total serum protein showed a tendency to decrease accompanied by a decrease in A/G ratio. Administration of adenosine-5-monophosphate prevented the increase in serum-alkaline phosphatase and increased the A/G ratio. There was, however, a slight but significant decrease in serum GOT and GPT within the 24-hrs. period of study, but it remained still higher than that of the control. AMP lowered liver fat without complete protection against the development of fatty liver.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Intoxicação por Tetracloreto de Carbono
/
AMP Cíclico
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Z Ernahrungswiss
Ano de publicação:
1977
Tipo de documento:
Article