Controllable and uncontrollable Stanford type B aortic dissection in canine models.
Eur Surg Res
; 44(3-4): 179-84, 2010.
Article
em En
| MEDLINE
| ID: mdl-20424461
ABSTRACT
BACKGROUND/AIMS:
Stanford type A and type B aortic dissections are anatomically distinct. Few animal models appropriately mimic human aortic dissection in the clinical setting. We developed animal models that mimicked uncontrollable Stanford type B aortic dissection as well as controllable dissection.METHODS:
Twelve female beagle dogs were randomly assigned to the uncontrollable dissection model, and 8 to the controllable. After creation of the false lumen using a self-made separator, epinephrine was injected acutely in the uncontrollable model, and a rapid injection of saline expanded the false lumen in the controllable model using a balloon catheter.RESULTS:
All models mimicked Stanford type B dissection at autopsy. Dissections formed in 9 of the 12 animals of the uncontrollable model as confirmed by digital subtraction angiography (DSA) performed 1 week after surgery. For the controllable dissection model, 6 out of 8 animals survived, and dissection was confirmed by DSA. Occlusion of the dissection developed 4 weeks after surgery in all 6 cases.CONCLUSIONS:
We have developed an easy, stable animal model of Stanford type B dissection which provides a great length of false lumen and appears very similar to aortic dissection in humans.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aneurisma da Aorta Torácica
/
Dissecção Aórtica
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Eur Surg Res
Ano de publicação:
2010
Tipo de documento:
Article