Effects of prenatal exposure to tributyltin and trihexyltin on behaviour in rats.
Neurotoxicol Teratol
; 13(1): 99-105, 1991.
Article
em En
| MEDLINE
| ID: mdl-2046631
ABSTRACT
The effects of prenatal administration of tributyltin (1 and 5 mg/kg) and trihexyltin (5 mg/kg) upon the development and behavioural repertoire of rats were studied. The dose levels were selected so as not to induce maternal toxicity. No consistent delay upon occurrence of various maturation markers of the organotin-treated offspring was seen. As adults the tributyltin-treated offspring showed considerable hyperactivity following the initial habituation whereas the trihexyltin-treated offspring showed hyperactivity to a lesser degree. In the spatial learning tasks applied, the radial arm maze and the circular swim maze, tributyltin-treated rats demonstrated a clearly retarded aquisition of the radial arm maze task whereas trihexyltin-treated rats performed as well as the control rats; no differences were obtained in the swim maze task. The tributyltin-treated offspring showed a drastic potentiation of d-amphetamine-induced hyperactivity, whereas trihexyltin treatment induced only a marginal increase.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Trialquitina
/
Comportamento Animal
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Neurotoxicol Teratol
Assunto da revista:
NEUROLOGIA
/
TOXICOLOGIA
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Suécia