Dynamic CT perfusion imaging of intra-axial brain tumours: differentiation of high-grade gliomas from primary CNS lymphomas.
Eur Radiol
; 20(10): 2482-90, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20495977
ABSTRACT
INTRODUCTION:
Perfusion computed tomography (PCT) allows to quantitatively assess haemodynamic characteristics of brain tissue. We investigated if different brain tumor types can be distinguished from each other using Patlak analysis of PCT data.METHODS:
PCT data from 43 patients with brain tumours were analysed with a commercial implementation of the Patlak method. Four patients had low-grade glioma (WHO II), 31 patients had glioblastoma (WHO IV) and eight patients had intracerebral lymphoma. Tumour regions of interest (ROIs) were drawn in a morphological image and automatically transferred to maps of cerebral blood flow (CBF), cerebral blood volume (CBV) and permeability (K (Trans)). Mean values were calculated, group differences were tested using Wilcoxon and Mann Whitney U-tests.RESULTS:
In comparison with normal parenchyma, low-grade gliomas showed no significant difference of perfusion parameters (p > 0.05) , whereas high-grade gliomas demonstrated significantly higher values (p < 0.0001 for K (Trans), p < 0.0001 for CBV and p = 0.0002 for CBF). Lymphomas displayed significantly increased mean K(Trans) values compared with unaffected cerebral parenchyma (p = 0.0078) but no elevation of CBV. High-grade gliomas show significant higher CBV values than lymphomas (p = 0.0078).DISCUSSION:
PCT allows to reliably classify gliomas and lymphomas based on quantitative measurements of CBV and K (Trans).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Tomografia Computadorizada por Raios X
/
Neoplasias do Sistema Nervoso Central
/
Glioma
/
Linfoma
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha