Prostaglandins mediate the compensatory responses to hemorrhage in the small intestine of the rat.
J Surg Res
; 50(6): 584-8, 1991 Jun.
Article
em En
| MEDLINE
| ID: mdl-2051769
ABSTRACT
We examined the effect of fixed-volume hemorrhage (10 ml/kg) on microvascular diameters and blood flow in the small intestine of the rat using in vivo videomicroscopic techniques. We found that hemorrhage in the absence of a potent cyclooxygenase inhibitor results in a transient decrease in intestinal blood flow and a preferential redistribution of intramural blood flow toward the mucosa because of a localized vasodilator response of the premucosal microvessels. In the presence of the selective cyclooxygenase inhibitor, mefenamic acid, the decrease in intestinal blood flow was more substantial and prolonged, and the localized vasodilator response of the premucosal microvasculature was abolished. Our results suggest that vasodilator prostaglandins contribute to the compensatory response of the intestine to hemorrhage and are responsible for the shunting of blood toward the mucosa during hemorrhagic hypotension.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adaptação Fisiológica
/
Prostaglandinas
/
Hemorragia Gastrointestinal
Limite:
Animals
Idioma:
En
Revista:
J Surg Res
Ano de publicação:
1991
Tipo de documento:
Article