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An event-related source localization study of response monitoring and social impairments in autism spectrum disorder.
Santesso, Diane L; Drmic, Irene E; Jetha, Michelle K; Bryson, Susan E; Goldberg, Joel O; Hall, Geoffrey B; Mathewson, Karen J; Segalowitz, Sidney J; Schmidt, Louis A.
Afiliação
  • Santesso DL; Department of Psychology, Brock University, St. Catharines, Ontario, CanadaDepartment of Psychology, York University, Toronto, Ontario, CanadaDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, CanadaIWK Health Centre, Departments of Pediatrics and Psychol
  • Drmic IE; Department of Psychology, Brock University, St. Catharines, Ontario, CanadaDepartment of Psychology, York University, Toronto, Ontario, CanadaDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, CanadaIWK Health Centre, Departments of Pediatrics and Psychol
  • Jetha MK; Department of Psychology, Brock University, St. Catharines, Ontario, CanadaDepartment of Psychology, York University, Toronto, Ontario, CanadaDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, CanadaIWK Health Centre, Departments of Pediatrics and Psychol
  • Bryson SE; Department of Psychology, Brock University, St. Catharines, Ontario, CanadaDepartment of Psychology, York University, Toronto, Ontario, CanadaDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, CanadaIWK Health Centre, Departments of Pediatrics and Psychol
  • Goldberg JO; Department of Psychology, Brock University, St. Catharines, Ontario, CanadaDepartment of Psychology, York University, Toronto, Ontario, CanadaDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, CanadaIWK Health Centre, Departments of Pediatrics and Psychol
  • Hall GB; Department of Psychology, Brock University, St. Catharines, Ontario, CanadaDepartment of Psychology, York University, Toronto, Ontario, CanadaDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, CanadaIWK Health Centre, Departments of Pediatrics and Psychol
  • Mathewson KJ; Department of Psychology, Brock University, St. Catharines, Ontario, CanadaDepartment of Psychology, York University, Toronto, Ontario, CanadaDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, CanadaIWK Health Centre, Departments of Pediatrics and Psychol
  • Segalowitz SJ; Department of Psychology, Brock University, St. Catharines, Ontario, CanadaDepartment of Psychology, York University, Toronto, Ontario, CanadaDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, CanadaIWK Health Centre, Departments of Pediatrics and Psychol
  • Schmidt LA; Department of Psychology, Brock University, St. Catharines, Ontario, CanadaDepartment of Psychology, York University, Toronto, Ontario, CanadaDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, CanadaIWK Health Centre, Departments of Pediatrics and Psychol
Psychophysiology ; 48(2): 241-51, 2011 Feb.
Article em En | MEDLINE | ID: mdl-20557481
A number of studies suggest anterior cingulate cortex (ACC) abnormalities in autism spectrum disorder (ASD), which might underlie response monitoring and social impairments exhibited by children and adolescents with ASD. The goal of the present study was to extend this work by examining error and correct response monitoring using event-related potentials (ERN, Pe, CRN) and LORETA source localization in high functioning adults with ASD and controls. Adults with ASD showed reduced ERN and Pe amplitudes and reduced rostral ACC activation compared with controls. Adults with ASD also showed less differentiation between error and correct ERP components. Social impairments and higher overall autism symptoms were related to reduced rostral ACC activity at the time of the ERN, particularly in adults with ASD. These findings suggest that reduced ACC activity may reflect a putative brain mechanism involved in the origins and maintenance of social impairments and raise the possibility of the presence of stable brain-behavior relation impairment across development in some individuals with ASD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Percepção Social / Potenciais Evocados / Função Executiva / Transtorno do Espectro Autista / Giro do Cíngulo Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychophysiology Ano de publicação: 2011 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Percepção Social / Potenciais Evocados / Função Executiva / Transtorno do Espectro Autista / Giro do Cíngulo Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychophysiology Ano de publicação: 2011 Tipo de documento: Article País de publicação: Estados Unidos