IgA pemphigus associated with monoclonal gammopathy completely resolved after achievement of complete remission of multiple myeloma with bortezomib, cyclophosphamide and dexamethasone regimen.
Wien Klin Wochenschr
; 122(9-10): 311-4, 2010 May.
Article
em En
| MEDLINE
| ID: mdl-20559888
ABSTRACT
Monoclonal gammopathy-associated IgA pemphigus is a debilitating skin disorder with inconsistent response to treatment. A 61-year-old woman with IgA pemphigus and monoclonal gammopathy of unknown significance had been treated unsuccessfully with cyclophosphamide/dexamethasone and then with rituximab. When the monoclonal gammopathy progressed to multiple myeloma, the patient received treatment with cyclophosphamide/doxorubicin/dexamethasone but there was no clinical response. Second-line therapy with a thalidomide/cyclophosphamide/dexamethasone combination led to severe exacerbation of the skin disorder. However, therapy with a combination regimen that included bortezomib, cyclophosphamide and dexamethasone resulted in complete and durable remission of multiple myeloma and IgA pemphigus. This suggests that bortezomib-based therapy is useful for the treatment of the rare dermatologic disorder associated with IgA gammopathy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paraproteinemias
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Pênfigo
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Deficiência de IgA
/
Mieloma Múltiplo
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
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Middle aged
Idioma:
En
Revista:
Wien Klin Wochenschr
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
República Tcheca