Positive effects of early continuous positive airway pressure on pulmonary function in extremely premature infants: results of a subgroup analysis of the COIN trial.
Arch Dis Child Fetal Neonatal Ed
; 96(5): F371-3, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-20584798
ABSTRACT
OBJECTIVE:
Early continuous positive airway pressure (CPAP) may reduce lung injury in preterm infants. PATIENTS ANDMETHODS:
Spontaneously breathing preterm infants were randomised immediately after birth to nasal CPAP or intubation, surfactant treatment and mechanical ventilation. Pulmonary function tests approximately 8 weeks post-term determined tidal breathing parameters, respiratory mechanics and functional residual capacity (FRC).RESULTS:
Seventeen infants received CPAP and 22 mechanical ventilation. Infants with early CPAP had less mechanical ventilation (4 vs 7.5 days; p=0.004) and less total respiratory support (30 vs 47 days; p=0.017). Post-term the CPAP group had lower respiratory rate (41 vs 48/min; p=0.007), lower minute ventilation (223 vs 265 ml/min/kg; p=0.009), better respiratory compliance (0.99 vs 0.82 ml/cm H(2)O/kg; p=0.008) and improved elastic work of breathing (p=0.004). No differences in FRC were found.CONCLUSIONS:
Early CPAP is feasible, shortens the duration of respiratory support and results in improved lung mechanics and decreased work of breathing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Positiva Contínua nas Vias Aéreas
/
Lesão Pulmonar
/
Doenças do Prematuro
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Arch Dis Child Fetal Neonatal Ed
Assunto da revista:
PEDIATRIA
/
PERINATOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha