LC-MS/MS studies of ritonavir and its forced degradation products.
J Pharm Biomed Anal
; 53(4): 833-42, 2010 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-20619992
ABSTRACT
Forced degradation of ritonavir (RTV), under the conditions of hydrolysis (acidic, basic and neutral), oxidation, photolysis and thermal stress as prescribed by ICH was studied using LC-MS/MS. Eight degradation products were formed and their separation was accomplished on Waters XTerra C(18) column (250 mm x 4.6 mm i.d., 5 microm) using watermethanolacetonitrile as (402040, v/v/v) mobile phase in an isocratic elution mode by LC. The method was extended to LC-MS/MS for characterization of the degradation products and the pathways of decomposition were proposed. No previous reports were found in the literature regarding the characterization of degradation products of ritonavir.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatografia Líquida de Alta Pressão
/
Cromatografia Líquida
/
Inibidores da Protease de HIV
/
Ritonavir
/
Espectrometria de Massas em Tandem
Idioma:
En
Revista:
J Pharm Biomed Anal
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Índia