Interaction of blockers of ionotropic NMDA receptors and metabotropic glutamate receptors in a working memory test in rats.
Neurosci Behav Physiol
; 40(7): 807-11, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20635207
ABSTRACT
Glutamate, the main excitatory neurotransmitter in the mammalian CNS, acts via ionotropic and metabotropic receptors. Results from in vitro studies demonstrating tight interactions between ionotropic NMDA receptors and subtype 5 metabotropic glutamate receptors (mGlu5) have shown that blockade of mGlu5 receptors increases the behavioral effects of NMDA receptor antagonists. The aim of the present work was to study the actions of the highly selective mGlu5 receptor antagonist MTEP alone and in combination with MK-801, a blocker of the NMDA receptor-associated ion channel, on performance of a delayed selection task (a test of working memory) in rats. MK-801 (0.1 mg/kg) induced a specific impairment to working memory, with proactive interference (degradation of the ability to remember current information because of the effects of previously learned material). Administration of MTEP (5.0 mg/kg) combined with both solvent and with MK-801 had no significant effects, demonstrating the small or nonexistent involvement of mGlu5 receptors in the mechanisms of working memory.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
N-Metilaspartato
/
Receptores de Glutamato Metabotrópico
/
Memória de Curto Prazo
Limite:
Animals
Idioma:
En
Revista:
Neurosci Behav Physiol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Federação Russa