Local Heschl's Gyrus-based coordinate system for intersubject comparison of M50 auditory response modeled by single equivalent current dipole.
J Neurosci Methods
; 192(1): 121-6, 2010 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-20655328
ABSTRACT
Allocating electromagnetic auditory responses to active regions in the human auditory cortex can be difficult because of high interindividual variability of the relevant structures. Location and orientation of the primary auditory cortex (Heschl's Gyrus) and the temporal plane vary with individual features such as age, gender, handedness, or between healthy subjects and patients with a psychiatric disorder (e.g., schizophrenia). Here, we propose a reference coordinate system that considers the individual MRI-based position, orientation and length of the primary auditory cortex to account for interindividual variability. Transformation of the M50 dipole localizations in this new HG-(Heschl's-Gyrus)-coordinate system, accomplished for 10 healthy subjects and 10 schizophrenia patients, confirmed group difference more precisely than other registration methods. We suggest to use the HG-coordinate system for localization of functional measures and evaluation of brain activity differences between groups or measurement conditions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orientação
/
Esquizofrenia
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Córtex Auditivo
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Potenciais Evocados Auditivos
Limite:
Adult
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neurosci Methods
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha