Your browser doesn't support javascript.
loading
A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness.
Dong, Yanbin; Stallmann-Jorgensen, Inger S; Pollock, Norman K; Harris, Ryan A; Keeton, Daniel; Huang, Ying; Li, Ke; Bassali, Reda; Guo, De-huang; Thomas, Jeffrey; Pierce, Gary L; White, Jennifer; Holick, Michael F; Zhu, Haidong.
Afiliação
  • Dong Y; Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA. ydong@mail.mcg.edu
J Clin Endocrinol Metab ; 95(10): 4584-91, 2010 Oct.
Article em En | MEDLINE | ID: mdl-20660028
CONTEXT: Vitamin D insufficiency/deficiency is commonly observed in black youth. OBJECTIVE: The aim was to determine 25-hydroxyvitamin D [25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV). DESIGN: We conducted a randomized, blinded, controlled clinical trial. SETTING AND PARTICIPANTS: Forty-nine normotensive black boys and girls, aged 16.3 ± 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25). RESULTS: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 ± 10.6, 44.9 ± 9.4, 51.2 ± 11.1, and 59.8 ± 18.2 nmol/liter, respectively, for the control group; and 33.1 ± 8.7, 55.0 ± 11.8, 70.9 ± 22.0, and 85.7 ± 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 ± 0.53 m/sec) to posttest (5.71 ± 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 ± 0.73 m/sec) to posttest (5.33 ± 0.79 m/sec) (P = 0.031). CONCLUSION: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artérias / Calcifediol / Doenças Cardiovasculares / Adolescente / Colecalciferol / População Negra / Adiposidade Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Female / Humans / Male Idioma: En Revista: J Clin Endocrinol Metab Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artérias / Calcifediol / Doenças Cardiovasculares / Adolescente / Colecalciferol / População Negra / Adiposidade Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Female / Humans / Male Idioma: En Revista: J Clin Endocrinol Metab Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos