Plasma concentrations of buprenorphine after epidural administration in conscious cats.
Res Vet Sci
; 90(3): 480-3, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-20709341
ABSTRACT
Buprenorphine plasma concentrations were measured after administering buprenorphine (20 µg/kg) into the lumbosacral epidural space of conscious cats chronically instrumented with an epidural catheter. Blood was collected from a jugular vein before injection and 15, 30, 45 and 60 min and 2, 3, 4, 5, 6, 8, 12 and 24 h after administration. Plasma buprenorphine concentrations were measured using ELISA. Background concentration (before injection) was 1.27 ± 0.27 ng/mL (mean ± SD). Including background concentration, the mean peak plasma concentration was obtained 15 min after injection (5.82 ± 3.75 ng/mL), and ranged from 3.79 to 2.20 ng/mL (30 min-3 h), remaining between 1.93 and 1.77 ng/mL (4-12 h), and declined to 1.40 ± 0.62 ng/mL at 24h. Elimination half-life was 58.8 ± 40.2 min and clearance 56.7 ± 21.5 mL/min. Results indicate early rapid systemic uptake of buprenorphine from epidural administration with plasma concentrations similar to using buccal or IM routes by 15 min postinjection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Buprenorfina
/
Entorpecentes
Limite:
Animals
Idioma:
En
Revista:
Res Vet Sci
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Canadá