Cathepsin D messenger RNA is downregulated in human lung cancer.
Biomarkers
; 15(7): 608-13, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-20722505
ABSTRACT
OBJECTIVES:
Lysosomal proteases cathepsins B and D (CB and CD) play a significant part in cancer progression. For many oncological diseases protein expression levels of CB and CD have been investigated and correlations with tumour characteristics revealed. Meanwhile, there is very little information concerning mRNA expression level.METHODS:
In the present work, data about mRNA levels of CB and CD in human lung cancer was obtained using reverse transcription followed by real-time polymerase chain reaction.RESULTS:
For the first time CD and CB mRNA in human lung cancer tumours was quantified. It was shown that CB and CD mRNA levels do not correlate with any tumour characteristics. However, in most analysed tumours, expression of CD mRNA was downregulated compared with adjacent normal tissue (p <0.0003).CONCLUSIONS:
The data obtained indicate CD mRNA as a potential lung cancer marker.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Biomarcadores Tumorais
/
Regulação para Baixo
/
Catepsina D
/
Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Revista:
Biomarkers
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Federação Russa