A fungicidal piperazine-1-carboxamidine induces mitochondrial fission-dependent apoptosis in yeast.
FEMS Yeast Res
; 10(7): 812-8, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-20726898
To unravel the working mechanism of the fungicidal piperazine-1-carboxamidine derivative BAR0329, we found that its intracellular accumulation in Saccharomyces cerevisiae is dependent on functional lipid rafts. Moreover, BAR0329 induced caspase-dependent apoptosis in yeast, in which the mitochondrial fission machinery consisting of Fis1 (Whi2), Dnm1 and Mdv1 is involved. Our data are consistent with a prosurvival function of Fis1 (Whi2) and a proapoptotic function of Dnm1 and Mdv1 during BAR0329-induced yeast cell death.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Saccharomyces cerevisiae
/
Apoptose
/
Mitocôndrias
/
Antifúngicos
Idioma:
En
Revista:
FEMS Yeast Res
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Bélgica
País de publicação:
Reino Unido