Impaired interferon-alpha enhancement of neonatal monocyte phagocytosis.
Biol Neonate
; 58(5): 260-3, 1990.
Article
em En
| MEDLINE
| ID: mdl-2076444
ABSTRACT
Monocyte phagocytic activity was tested in 10 healthy term newborns using a latex phagocytic assay. The baseline phagocytic activity in the cord blood monocytes (37.7 +/- 3.8%) was comparable to adult controls (38.5 +/- 9.4%). When enhanced with 1,000 U/ml of alpha-interferon, the phagocytic activity was lower in cord blood monocytes (40.5 +/- 3.4%) than in the adult controls (47.9 +/- 10.6%), but this difference reached statistical significance only when the cord blood monocytes were enhanced with 2,000 U/ml reaching 43.6 +/- 4.3% in cord blood monocytes, as compared to 54.6 +/- 9.6% in adult controls. These findings may explain an inherent functional deficiency in the neonatal mononuclear phagocytic system which may not be evident during the quiescent phase of monocyte/macrophage activity, but may become apparent during an infectious challenge.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Leucócitos Mononucleares
/
Interferon Tipo I
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Biol Neonate
Ano de publicação:
1990
Tipo de documento:
Article