Heterocellular induction of interferon by negative-sense RNA viruses.
Virology
; 407(2): 247-55, 2010 Nov 25.
Article
em En
| MEDLINE
| ID: mdl-20833406
ABSTRACT
The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus and bunyamwera virus. We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
/
Vírus Bunyamwera
/
Paramyxoviridae
/
Interferon Tipo I
/
Rim
/
Pulmão
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Virology
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido