[Correlation of ornidazole concentration in saliva and serum of healthy volunteers].
Nan Fang Yi Ke Da Xue Xue Bao
; 30(9): 2108-10, 2010 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-20855263
ABSTRACT
OBJECTIVE:
To investigate the distribution of ornidazole in the salivary and serum of healthy adults and explore the feasibility of monitoring serum drug concentration with salivary.METHODS:
Six volunteers received a single dose of 0.6 g ornidazole via intravenous infusion. The concentrations of ornidazole in the saliva and serum were assayed by high-performance liquid chomatography, and the correlation of the drug concentrations in saliva to that in serum was analyzed.RESULTS:
The concentration of ornidazole in the saliva was strongly associated with that in the serum (r = 0.825-0.969), and the ratio of saliva-to-serum concentration (S/P) of ornidazole was 0.99 ± 0.13.CONCLUSION:
Detection of saliva ornidazole concentration is feasible for monitoring the therapeutic concentration of ornidazole.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ornidazol
/
Saliva
/
Antibacterianos
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China