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The Comparative Toxicogenomics Database: update 2011.
Davis, Allan Peter; King, Benjamin L; Mockus, Susan; Murphy, Cynthia G; Saraceni-Richards, Cynthia; Rosenstein, Michael; Wiegers, Thomas; Mattingly, Carolyn J.
Afiliação
  • Davis AP; Department of Bioinformatics, The Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.
Nucleic Acids Res ; 39(Database issue): D1067-72, 2011 Jan.
Article em En | MEDLINE | ID: mdl-20864448
The Comparative Toxicogenomics Database (CTD) is a public resource that promotes understanding about the interaction of environmental chemicals with gene products, and their effects on human health. Biocurators at CTD manually curate a triad of chemical-gene, chemical-disease and gene-disease relationships from the literature. These core data are then integrated to construct chemical-gene-disease networks and to predict many novel relationships using different types of associated data. Since 2009, we dramatically increased the content of CTD to 1.4 million chemical-gene-disease data points and added many features, statistical analyses and analytical tools, including GeneComps and ChemComps (to find comparable genes and chemicals that share toxicogenomic profiles), enriched Gene Ontology terms associated with chemicals, statistically ranked chemical-disease inferences, Venn diagram tools to discover overlapping and unique attributes of any set of chemicals, genes or disease, and enhanced gene pathway data content, among other features. Together, this wealth of expanded chemical-gene-disease data continues to help users generate testable hypotheses about the molecular mechanisms of environmental diseases. CTD is freely available at http://ctd.mdibl.org.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença / Bases de Dados Factuais / Toxicogenética / Exposição Ambiental Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença / Bases de Dados Factuais / Toxicogenética / Exposição Ambiental Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido