Cerebrospinal fluid leak during treatment with bevacizumab and irinotecan after carmustine-impregnated wafers placement in patients with grade 2 oligodendroglioma and glioblastoma multiforme: report of two cases and review of literature.
Cancer Invest
; 28(10): 1048-53, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-20873990
ABSTRACT
Placement of carmustine-impregnated wafers has become a common practice after surgical resection of malignant gliomas. Bevacizumab is used as a second-line agent for the treatment of malignant gliomas and is sometimes used in patients who have had recent wafer implantation. We describe two cases of fatal cerebrospinal fluid (CSF) leak in patients treated with bevacizumab and irinotecan after 4 weeks of carmustine wafer implantation. Possible mechanisms for the CSF leak in these patients are discussed. We recommend waiting for a longer period of time before starting bevacizumab in patients who had implantation of carmustine wafers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligodendroglioma
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Neoplasias Encefálicas
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Carmustina
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Protocolos de Quimioterapia Combinada Antineoplásica
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Glioblastoma
Limite:
Aged
/
Aged80
/
Female
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Humans
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Male
Idioma:
En
Revista:
Cancer Invest
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos