Chromosome 5 and 7 abnormalities in oncology personnel handling anticancer drugs.
J Occup Environ Med
; 52(10): 1028-34, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20881619
ABSTRACT
OBJECTIVE:
To determine the frequency of "signature" chromosomal abnormalities in oncology workers handling anticancer drugs.METHODS:
Peripheral blood from health care personnel (N = 109) was examined with probes for targets on chromosomes 5, 7, and 11. The effect of drug-handling frequency on chromosome abnormalities was assessed.RESULTS:
An excess of structural (0.18 vs 0.02; P = 0.04) and total abnormalities (0.29 vs 0.04; P = 0.01) of chromosome 5 was observed in the high-exposure group compared with the unexposed. Increased incidence rate ratios (IRRs) for abnormalities of chromosome 5 (IRR = 1.24; P = 0.01) and for either chromosome 5 or 7 (IRR = 1.20; P = 0.01) were obtained at 100 handling events. Effect sizes were augmented 2- to 4-fold when alkylating agent handling alone was considered.CONCLUSIONS:
Biologically important exposure to genotoxic drugs is apparently occurring in oncology work settings despite reported use of safety practices.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Cromossomos Humanos Par 5
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Cromossomos Humanos Par 7
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Aberrações Cromossômicas
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Oncologia
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Antineoplásicos
Limite:
Adult
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Occup Environ Med
Assunto da revista:
MEDICINA OCUPACIONAL
/
SAUDE AMBIENTAL
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos