[The subacute toxicity of glucosylthiazolidine-4-carbonic acid in rats]. / Untersuchung der subakuten Toxizität von Glucosylthiazolidin-4-carbonsäure an Ratten.
Nahrung
; 34(7): 623-8, 1990.
Article
em De
| MEDLINE
| ID: mdl-2089262
ABSTRACT
Glucosylthiazolidine-4-carbonic acid, an intermediate of the Maillard reaction between D-glucose and L-cysteine, was given in doses of 0, 25, 50 or 100 mg/kg b.w. by oral intubation to male and female rats for 21 days. General appearance, growth, food consumption, haematology, urine analysis and serum chemistry including determinations of enzyme activities, organ weights and macroscopic and microscopic pathology were used as criteria for adverse effects. Effects on the kidneys were indicated by oliguria and decreased specific gravity of the urine in males and histopathological changes of the proximal tubules in females. The no-effect dose established from this study is 25 mg/kg b.w.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Reação de Maillard
/
Glucosídeos
/
Rim
Limite:
Animals
Idioma:
De
Revista:
Nahrung
Ano de publicação:
1990
Tipo de documento:
Article