The central inhibitory effect of interleukin-1 on gastric acid secretion.
Neurosci Lett
; 119(1): 114-7, 1990 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-2097573
ABSTRACT
The effect of interleukin-1 (IL-1) on gastric secretory functions was examined in pylorus-ligated conscious rats. Intracisternal (i.c.) injection of IL-1 beta (1-100 ng) induced dose-related, long-lasting inhibition of gastric acid output, which was due to the reductions of both the amount and the acid concentration of the gastric juice. A much higher dose of IL-1 alpha was required to achieve identical effects on gastric acid secretion when it was given by intravenous routes. The i.c. injection of IL-1 alpha also had an inhibition of gastric secretion. This inhibitory effect of i.c. applied IL-1 beta on gastric acid secretion was completely abolished in indomethacin-pretreated animals but not in reserpine-pretreated ones. These results suggest that IL-1 may have an inhibitory action on the regulation of gastric secretory functions by its central action which is dependent on the eicosanoid metabolism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Interleucina-1
/
Ácido Gástrico
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão