Your browser doesn't support javascript.
loading
Intraerythrocytic stages of Plasmodium falciparum biosynthesize menaquinone.
Tonhosolo, Renata; Gabriel, Heloisa B; Matsumura, Miriam Y; Cabral, Fernanda J; Yamamoto, Márcio M; D'Alexandri, Fábio L; Sussmann, Rodrigo A C; Belmonte, Rodrigo; Peres, Valnice J; Crick, Dean C; Wunderlich, Gerhard; Kimura, Emília A; Katzin, Alejandro M.
Afiliação
  • Tonhosolo R; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Gabriel HB; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Matsumura MY; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Cabral FJ; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Yamamoto MM; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • D'Alexandri FL; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Sussmann RAC; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Belmonte R; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Peres VJ; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Crick DC; Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus Delivery Ft., Collins, CO 80523-1677, USA.
  • Wunderlich G; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Kimura EA; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Katzin AM; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
FEBS Lett ; 584(23): 4761-4768, 2010 Dec 01.
Article em En | MEDLINE | ID: mdl-21036171
ABSTRACT
Herein, we show that intraerythrocytic stages of Plasmodium falciparum have an active pathway for biosynthesis of menaquinone. Kinetic assays confirmed that plasmodial menaquinone acts at least in the electron transport. Similarly to Escherichia coli, we observed increased levels of menaquinone in parasites kept under anaerobic conditions. Additionally, the mycobacterial inhibitor of menaquinone synthesis Ro 48-8071 also suppressed menaquinone biosynthesis and growth of parasites, although off-targets may play a role in this growth-inhibitory effect. Due to its absence in humans, the menaquinone biosynthesis can be considered an important drug target for malaria.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Vitamina K 2 / Eritrócitos / Estágios do Ciclo de Vida Limite: Animals Idioma: En Revista: FEBS Lett Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Vitamina K 2 / Eritrócitos / Estágios do Ciclo de Vida Limite: Animals Idioma: En Revista: FEBS Lett Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil