Complete glutathione system in probiotic Lactobacillus fermentum ME-3.
Prikl Biokhim Mikrobiol
; 46(5): 527-31, 2010.
Article
em En
| MEDLINE
| ID: mdl-21058502
ABSTRACT
There is much information about glutathione (GSH) in eukaryotic cells, but relatively little is known about GSH in prokaryotes. Without GSH and glutathione redox cycle lactic acid bacteria (LAB) cannot protect themselves against reactive oxygen species. Previously we have shown the presence of GSH in Lactobacillus fermentum ME-3 (DSM14241). Results of this study show that probiotic L. fermentum ME-3 contains both glutathione peroxidase and glutathione reductase. We also present that L. fermentum ME-3 can transport GSH from environment and synthesize GSH. This means that it is characterized by a complete glutathione system synthesis, uptake and redox turnover ability that makes L. fermentum ME-3 a perfect protector against oxidative stress. To our best knowledge studies on existence of the complete glutathione system in probiotic LAB strains are still absent and glutathione synthesis in them has not been demonstrated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espécies Reativas de Oxigênio
/
Estresse Oxidativo
/
Probióticos
/
Limosilactobacillus fermentum
/
Glutationa
Idioma:
En
Revista:
Prikl Biokhim Mikrobiol
Ano de publicação:
2010
Tipo de documento:
Article