Internal dynamics of actin structures involved in the cell motility and adhesion: Modeling of the podosomes at the molecular level.
J Theor Biol
; 270(1): 25-30, 2011 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-21075123
ABSTRACT
Podosomes are involved in the spreading and motility of various cells to a solid substrate. These dynamical structures, which have been proven to consist of a dense actin core surrounded by an actin cloud, nucleate when the cell comes in the vicinity of a substrate. During the cell spreading or motion, the podosomes exhibit collective dynamical behaviors, forming clusters and rings. We design a simple model aiming at the description of internal molecular turnover in a single podosome actin filaments form a brush which grows from the cellular membrane whereas their size is regulated by the action of a severing agent, the gelsolin. In this framework, the characteristic sizes of the core and of the cloud, as well as the associated characteristic times are expressed in terms of basic ingredients. Moreover, the collocation of the actin and gelsolin in the podosome is understood as a natural result of the internal dynamics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto de Actina
/
Adesão Celular
/
Movimento Celular
/
Extensões da Superfície Celular
/
Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Theor Biol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
França