Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin.
J Nutr
; 120(5): 444-9, 1990 May.
Article
em En
| MEDLINE
| ID: mdl-2111377
ABSTRACT
There were no statistically significant differences in final body weight or in food intake among groups of rats fed for 7 wk various fats of animal origin (lard fat and cod liver oil) or vegetable origin (corn, soybean and canola oils); the fats were fed as 10% of the diet (by wt) and were of varied fatty acid composition. Nevertheless, the mean weights of the kidneys from cod liver oil-fed animals were significantly higher than those of all other dietary groups. Platelets of rats from the groups receiving the animal fat contained significantly lower levels of linoleic acid, 182(n-6) [a precursor of arachidonic acid, 204(n-6)], than did platelets from rats receiving the fat of vegetable origin. Although the soybean-, canola- and cod liver oil-fed animals received substantial quantities of (n-3) fatty acids [alpha-linolenic acid, 183(n-3); eicosapentaenoic acid, 205(n-3); and docosahexaenoic acid, 226(n-3)], only the platelets of the latter two groups contained detectable levels of these fatty acids along with their products of elongation/desaturation/retroconversion. Platelets of the cod liver oil-fed group contained significantly less arachidonic acid, a major precursor of eicosanoids, than did those from all other dietary groups. However, platelet arachidonic levels also varied markedly among the other dietary groups. Diet-induced fatty acid changes observed in platelets of various dietary groups may influence platelet responses, including secretion, aggregation and biosynthesis of eicosanoids.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Óleos de Plantas
/
Óleo de Fígado de Bacalhau
/
Óleos de Peixe
/
Gorduras na Dieta
/
Ácidos Graxos
Limite:
Animals
Idioma:
En
Revista:
J Nutr
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Canadá