Tyrosine phosphatase inhibition attenuates early brain injury after subarachnoid hemorrhage in rats.
Acta Neurochir Suppl
; 110(Pt 1): 67-70, 2011.
Article
em En
| MEDLINE
| ID: mdl-21116917
ABSTRACT
PURPOSE:
Sodium orthovanadate (SOV) is a representative tyrosine phosphatase inhibitor and has been shown to ameliorate neuronal injury in cerebral ischemia. We hypothesized that tyrosine phosphatase inhibition by SOV might attenuate early brain injury after subarachnoid hemorrhage (SAH) in this study.METHODS:
The endovascular perforation model of SAH was produced and animals were randomly assigned to sham-operated rats, saline-treated (vehicle), and 10 mg/kg of SOV-treated SAH rats. Drugs were injected intraperitoneally immediately after SAH induction. Neurological score and brain water content (BWC) were assessed at 24 h after SAH. Cell injury was studied by terminal deoxynucleotidyl transferase-mediated uridine 5'-triphosphate-biotin nick end-labeling (TUNEL) at 24 h after SAH.RESULTS:
Severity of SAH and mortality in SOV-treated rats was similar to that of the saline group. SOV significantly decreased BWC and improved neurological score at 24 h after SAH compared with the saline group. SOV decreased TUNEL-positive cells at 24 h after SAH compared with the saline group.CONCLUSIONS:
These data suggest that tyrosine phosphatase inhibition by SOV ameliorates early brain injury after SAH.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Encefálicas
/
Vanadatos
/
Proteínas Tirosina Fosfatases
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Acta Neurochir Suppl
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos