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Increased sympathetic activity in chronic pancreatitis patients is associated with hyperalgesia.
Buscher, H C J L; van Goor, H; Sweep, C G J; Lenders, J W M; Wilder-Smith, O H G.
Afiliação
  • Buscher HC; Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
J Pain Palliat Care Pharmacother ; 24(4): 362-6, 2010 Dec.
Article em En | MEDLINE | ID: mdl-21133744
Pain treatment in chronic pancreatitis patients is difficult, with pain frequently relapsing or persisting. Recent studies suggest that altered central nervous system pain processing underlies the chronic pain state in these patients. There is evidence that increased sympathetic activity may also play a role in some chronic pain syndromes. This study assessed sympathetic nervous system activity and its relation to pain processing in patients with severe painful chronic pancreatitis. The authors postulated that chronic pancreatitis patients with more sympathetic activity exhibit more generalized hyperalgesia. In 16 chronic pancreatitis patients, sympathetic activity was measured via venous plasma norepinephrine (NE) levels (supine, standing). Pain processing was quantified via pressure pain tolerance thresholds (PPTs) in dermatomes T10 (pancreatic area), C5, T4, L1. Five patients showed increased supine plasma NE levels (NE ≥ 3.0 nmol/L). PPTs were lower in patients with increased NE levels (INE) compared with patients with normal NE (NNE) (means [95% confidence interval]: INE 402 kPa [286-517] versus NNE 522 kPa [444-600]; P = .042). In severe chronic pancreatitis patients, increased sympathetic activity and hyperalgesia appear associated, suggesting that sympathetic activity may also play a role in these patients' pain.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Simpático / Norepinefrina / Pancreatite Crônica / Hiperalgesia Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Pain Palliat Care Pharmacother Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Simpático / Norepinefrina / Pancreatite Crônica / Hiperalgesia Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Pain Palliat Care Pharmacother Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido