Novel steroidal saponins from Liriope graminifolia (Linn.) Baker with anti-tumor activities.
Carbohydr Res
; 346(2): 253-8, 2011 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-21163470
ABSTRACT
Phytochemical investigation of the underground parts of Liriope graminifolia (Linn.) Baker resulted in the isolation of two new steroidal saponins lirigramosides A (1) and B (2) along with four known compounds. The structures were determined by extensive spectral analysis, including two-dimensional (2D) NMR spectroscopy and chemical methods, to be 3-O-[ß-d-xylopyranosyl-(1â3)-α-l-arabinopyranosyl-(1â2)-[α-l-rhamnopyranosyl-(1â4)]-ß-d-glucopyranosyl-(25S)-spirost-5-ene-3ß,17α-diol (1), 1-O-[α-l-rhamnopyranosyl-(1â2)-ß-d-xylopyranosyl]-(25R)-ruscogenin (2), 1-O-ß-d-xylopyranosyl-3-O-α-l-rhamnopyranosyl-(25S)-ruscogenin (3), 3-O-α-l-rhamnopyranosyl-1-O-sulfo-(25S)-ruscogenin (4), methylophiopogonanone B (5), and 5,7-dihydroxy-3-(4-methoxybenzyl)-6-methyl-chroman-4-one, (ophiopogonanone B, 6), respectively. Compound 1 has a new (25S)-spirost-5-ene-3ß,17α-diol ((25S)-pennogenin) aglycone moiety. The isolated compounds were evaluated for their cytotoxic activities against Hela and SMMC-7721 cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saponinas
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Esteroides
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Liliaceae
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Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Carbohydr Res
Ano de publicação:
2011
Tipo de documento:
Article