Oxidative stress and atherogenesis. An FT-IR spectroscopic study.
In Vivo
; 24(6): 883-8, 2010.
Article
em En
| MEDLINE
| ID: mdl-21164049
ABSTRACT
Atherosclerosis is a complex phenomenon which leads to sudden death. Fourier transform infrared (FT-IR) spectroscopy was used to study the pathogenic components of carotids that produce the atheromatic plaque at the molecular level, as well as the role of free radicals, which are developed during oxidative stress and their effect on plaque generation. The absorption infrared spectra reflected significant changes which were analogous to clinical data of each patient. The spectra contained signature bands of the biological molecules which were characteristic for the plaque components. The bands found at about 3080 cm(-1) and 1736 cm(-1) were proportional to low-density lipoprotein concentration for each patient, suggesting the hydroperoxidation of lipids due to free radicals, generated during oxidative stress. From scanning electron microscopy analysis, it was found that the carotid plaques contained calcium minerals, silicon and heavy metals, such as copper, silver, lead and titanium, which were related to the working environment of the patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artérias Carótidas
/
Estresse Oxidativo
/
Aterosclerose
/
Placa Aterosclerótica
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
In Vivo
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Grécia