Bone marrow fat is inversely related to cortical bone in young and old subjects.
J Clin Endocrinol Metab
; 96(3): 782-6, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21177790
ABSTRACT
OBJECTIVE:
Recent studies suggest a close local link between bone marrow adiposity and endosteal bone formation. Using magnetic resonance imaging, we examined whether the relation between the amount of marrow fat and cortical bone is present at multiple sites along the diaphyses of the long bones of young and old males and females.DESIGN:
The relations between values for cortical bone area and percent marrow fat in each 5-mm section along the midthird of both femoral shafts were determined using magnetic resonance imaging in eight healthy young (aged <25 yr), and nine healthy old (aged >55 yr) men and women.RESULTS:
Strong inverse correlations were observed between values for cortical bone area and percent marrow fat along the shafts of all 34 femurs; r values between -0.54 to -0.97; all P values = 0.01-0.0001. The strength of this local association was comparable in the young and the elderly and in males and females.CONCLUSION:
Our results underscore the strength of the local connections between bone and marrow adiposity. Increasing our understanding of the mechanism for this association could lead to better diagnosis and treatment approaches for osteoporosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Envelhecimento
/
Metabolismo dos Lipídeos
Limite:
Adolescent
/
Adult
/
Aged
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Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos