[Effect of uncaria on evoked field potential of hippocampal slice in epileptogenic rat].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 17(3): 259-61, 2001 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-21189628
AIM: To investigate the effect of uncaria on evoked field potential of CA1 hippocampal slice in epileptogenic model. METHODS: We made rats which were injected by pilocarpine as epileptic-models. The pathway of drug administration is titration adjacent to hippocampal slices. We recorded the evoked field potential of hippocampal slice by glass microelectrode extracellularly, and observed the effect of uncaria on the amplitude of population spike (PS) in CA1 pyramidal cells in hippocampal slices. RESULTS: The uncaria with concentration of 1 g/ml could reduce the amplitude of PS in CA1 of hippocampal slices. The average of fall was 27.64%, and restored in 8.71 minutes on average (n = 14, P < 0.01). CONCLUSION: Uncaria could reduce the amplitude of PS in CA1 of epileptic hippocampal slices remarkably. These results show that uncaria can inhabited the synaptic transfer activity of CNS remarkably, suggest that it has the distinct effect of anti-epilepsy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uncaria
/
Epilepsia
/
Potenciais Evocados
/
Região CA1 Hipocampal
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Ying Yong Sheng Li Xue Za Zhi
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
China