Diagnostic accuracy of symptoms characterising chronic fatigue syndrome.
Disabil Rehabil
; 33(19-20): 1768-75, 2011.
Article
em En
| MEDLINE
| ID: mdl-21208154
ABSTRACT
PURPOSE:
To determine the diagnostic accuracy for single symptoms and clusters of symptoms to distinguish between individuals with and without chronic fatigue syndrome (CFS).METHODS:
A cohort study was conducted in an exercise physiology laboratory in an academic setting. Thirty subjects participated in this study (nâ=â16 individuals with CFS; nâ=â14 non-disabled sedentary matched control subjects). An open-ended symptom questionnaire was administered 1 week following the second of two maximal cardiopulmonary exercise tests administered 24 h apart.RESULTS:
Receiver operating characteristics (ROC) curve analysis was significant for failure to recover within 1 day (area under the curveâ = â0.864, 95% confidence interval [CI] 0.706-1.00, pâ=â0.001) but not within 7 days. Clinimetric properties of failure to recover within 1 day to predict membership in the CFS cohort were sensitivity 0.80, specificity 0.93, positive predictive value 0.92, negative predictive value 0.81, positive likelihood ratio 11.4, and negative likelihood ratio 0.22. Fatigue demonstrated high sensitivity and modest specificity to distinguish between cohorts, while neuroendocrine dysfunction, immune dysfunction, pain, and sleep disturbance demonstrated high specificity and modest sensitivity. ROC analysis suggested cut-point of three associated symptoms (0.871, 95% CI 0.717-1.00, pâ<â0.001). A significant binary logistic regression model (pâ<â0.001) revealed immune abnormalities, sleep disturbance and pain accurately classified 92% of individuals with CFS and 88% of control subjects.CONCLUSIONS:
A cluster of associated symptoms distinguishes between individuals with and without CFS. Fewer associated symptoms may be necessary to establish a diagnosis of CFS than currently described.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
/
Síndrome de Fadiga Crônica
/
Tolerância ao Exercício
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Disabil Rehabil
Assunto da revista:
REABILITACAO
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos