Formulation and evaluation of mouth dissolving tablets of cinnarizine.
Indian J Pharm Sci
; 72(4): 522-5, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-21218071
ABSTRACT
The purpose of this research was to develop mouth dissolve tablets of cinnarizine by effervescent, superdisintegrant addition and sublimation methods. All the three formulations were evaluated for disintegration time, hardness and friability, among these superdisintegrant addition method showed lowest disintegration time; hence it was selected for further studies. Further nine batches (B1-B9) were prepared by using crospovidone, croscarmellose sodium and L-HPC in different concentrations such as 5, 7.5 and 10%. All the formulations were evaluated for weight variation, hardness, friability, drug content, in vitro disintegration time, wetting time, in vitro dissolution. Formulation with 10% L-HPC showed the less disintegration time (25.3 s) and less wetting time (29.1 s). In vitro dissolution studies showed total drug release at the end of 6 min.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Indian J Pharm Sci
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Índia