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Inhibition of PDGF, TGF-ß, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.
Liu, Yuqing; Wang, Zhuo; Kwong, Shu Qin; Lui, Eric Lik Hang; Friedman, Scott L; Li, Fu Rong; Lam, Reni Wing Chi; Zhang, Guo Chao; Zhang, Hui; Ye, Tao.
Afiliação
  • Liu Y; Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China; Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, The Shenzhen Graduate School of Peking University, Shenzhen 518055, China. Electronic address: yuqing_liu@ho
  • Wang Z; Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
  • Kwong SQ; Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
  • Lui ELH; Department of Biochemistry, The University of Hong Kong, Hong Kong, China.
  • Friedman SL; Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA.
  • Li FR; Clinical Medical Research Center, The Second Clinic Medicine College, Shenzhen People's Hospital, Jinan University, Shenzhen 518020, China.
  • Lam RWC; Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
  • Zhang GC; Clinical Medical Research Center, The Second Clinic Medicine College, Shenzhen People's Hospital, Jinan University, Shenzhen 518020, China.
  • Zhang H; Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, The Shenzhen Graduate School of Peking University, Shenzhen 518055, China.
  • Ye T; Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China; Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, The Shenzhen Graduate School of Peking University, Shenzhen 518055, China. Electronic address: bctaoye@inet.
J Hepatol ; 55(3): 612-625, 2011 Sep.
Article em En | MEDLINE | ID: mdl-21251937
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Proteínas Tirosina Quinases / Fator de Crescimento Derivado de Plaquetas / Transdução de Sinais / Genes abl / Fator de Crescimento Transformador beta / Cirrose Hepática Limite: Animals / Humans / Male Idioma: En Revista: J Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de publicação: Holanda
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Proteínas Tirosina Quinases / Fator de Crescimento Derivado de Plaquetas / Transdução de Sinais / Genes abl / Fator de Crescimento Transformador beta / Cirrose Hepática Limite: Animals / Humans / Male Idioma: En Revista: J Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de publicação: Holanda