EEG coherence and symptom profiles of children with Attention-Deficit/Hyperactivity Disorder.
Clin Neurophysiol
; 122(7): 1327-32, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21310652
OBJECTIVE: We compared EEG coherence in children with and without AD/HD, and sought to relate observed anomalies to AD/HD symptoms. METHODS: Forty children with AD/HD and 40 age- and sex-matched controls had eyes-closed resting EEG coherence calculated for eight interhemispheric electrode pairs and eight intrahemispheric pairs (four within each hemisphere) in the delta, theta, alpha, beta and "40 Hz" gamma bands. RESULTS: At short-medium inter-electrode distances, the AD/HD group had increased intrahemispheric coherence in delta and theta, and reduced (L>R) laterality in delta, alpha, beta and gamma. Over longer inter-electrode distances, the AD/HD group had reduced intrahemispheric coherence in alpha. In interhemispheric comparisons, the AD/HD group had reduced frontal coherence in delta, alpha and gamma, increased temporal theta and reduced temporal alpha coherences, and increased central/parietal/occipital coherence in theta. Smaller left-lateralized coherences in AD/HD correlated negatively with DSM Inattentive and DSM Total scores, and smaller frontal interhemispheric coherence in alpha correlated negatively with DSM Hyperactive/Impulsive score. CONCLUSIONS: The negative correlations between AD/HD coherence anomalies and symptoms suggest that several anomalies reflect compensatory brain function. SIGNIFICANCE: Coherence differences in AD/HD may reflect anomalous frontal right-hemisphere linkages that help compensate functional brain anomalies in the left frontal regions in this disorder.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno do Deficit de Atenção com Hiperatividade
/
Eletroencefalografia
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Neurophysiol
Assunto da revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Austrália
País de publicação:
Holanda