FDG-PET/CT-guided biopsy of bone metastases sets a new course in patient management after extensive imaging and multiple futile biopsies.
Br J Radiol
; 84(999): e65-7, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21325361
ABSTRACT
A 73-year-old man with a history of prostate and bladder carcinoma and persistent back pain was diagnosed by MRI with multiple vertebral metastases including a compression fracture of T7. He received radiotherapy for pain relief and for vertebral instability with incipient spinal stenosis, but additional targeted systemic therapy was intended. Therefore, multiple attempts at minimally invasive and open biopsies for histological characterisation of the bone metastases were performed, but failed to provide a conclusive specimen, although CT, MRI and bone scintigraphy were used for biopsy planning. Only histopathological analysis of an (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT-guided additional biopsy at a site with high metabolic activity yielded the final diagnosis of bone metastases of a neuroendocrine small cell cancer of unknown origin; hence, the patient had a third malignancy requiring a different therapy regimen and diagnostic work-up.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Coluna Vertebral
/
Coluna Vertebral
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Neoplasias Primárias Desconhecidas
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Tumores Neuroendócrinos
/
Carcinoma de Células Pequenas
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Br J Radiol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha